Drugs combination
Thus, purpose of drugs combinations appears not as display of will of doctor, and as urgent command of modern drugs practice.
At the same time it is established, that medicinal substances form drugs entering into a composition cooperate not only with an organism, but drugs also among themselves. So the drug interaction can be not only desirable drugs interaction, used drugs interaction, but also undesirable drug interaction, even harmful. According to English authors, the majority of the hospitalized patients received on the average on 6 drugs simultaneously. Unexpected by-effects at them met in 7 times more often, than at those patients who received on 4 and less drugs simultaneously.
A significant part of these collateral reactions authors charge to interaction of drugs.
Resulted, practically often meeting combinations, naturally, do not limit opportunities of combinations salicylates (in particular, such preparation, as acetylsalicinic an acid) with other drugs. If, for example, to take 2000 widely used drugs the probable quantity of their combinations is expressed by the number which is falling outside the limits usual perceptions drugs: 64 х 10 (i.e. 64 with 18 zero).
Thus it is clear, that studying of interaction of drugs is huge and actually a plenty of scientific researches.
Interaction of drugs can be realized as intracorporeal, i.e. in internal environments of an organism, and extracorporeal - in drugs forms. Besides on the character interaction of drugs can be physicalinteraction of drugs, chemical interaction of drugs, pharmakinetik interaction of drugs and pharmacodynamical interaction of drugs.
Direct physical and chemical interaction of drugs happens more often extracorporal - in medicinal forms, and not in official, factory made and repeatedly checked up on compatibility ingredient, and in main, produced in a drugs store manually, on medical prescription. It is necessary to remember it. The result of physical or chemical interaction of combined drugs can essentially deform expected medical effect.